Please select the option that best describes you:
For multiple myeloma patients with vertebral lesions requiring palliative radiation (e.g. 20-30 Gy in 10fx), do you treat concurrently with modern systemic myeloma agents such as lenalidomide and bortezomib?
Which systemic agents would you recommend holding during RT?
Answer from: Radiation Oncologist at Community Practice
We found in an institutional retrospective experience that patients with MM can safely be treated with lenalidomide, bortezomib, and cytotoxic therapy with palliative xrt.https://www.ncbi.nlm.nih.gov/pubmed/25176474
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Answer from: Radiation Oncologist at Academic Institution
For palliative radiation, I do not treat myeloma with concurrent chemothereapy, although I may not ask the patients to stop their chemo if they are already on it.
Answer from: Radiation Oncologist at Community Practice
An additional large series was published showing no additional toxicity when XRT was added to newer biologic agents, though numerically, there does appear to be a trend towards increased acute morbidity of combined treatment:Salgado et al., PMID 30706018.