For patients with multiple myeloma, when using Lenalidomide or Pomalidomide, how do you approach dose adjustment based on patient tolerance?  

In general, my approach is to try to keep patients on the intended dose of an IMiD for as long as they can tolerate it (within reason). I think early dose reductions can be avoided by dedicated supportive care. For rashes, using antihistamines and topical corticosteroids can help. For diarrhea, imod...