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Given results of the RADICALS trials, is LT-ADT standard of care for salvage prostate RT?
Given the results of RADICALS/HD, RADICALS/RT trials, it seems as though there was no benefit to adding ST-ADT to RT, but a DFMS benefit for LT-ADT over ST-ADT.
I’m not sure I’m ready to routinely rx LT-ADT in all settings, especially in light of the other positive ST-ADT trials (GETUG, SPPORT) and known risks of LT-ADT (per 9601).
Answer from: Radiation Oncologist at Academic Institution
I do not think long-term ADT is established as standard of care for salvage prostate radiation, as this would require a demonstration of improved overall survival in at least specific subgroups of patients. RADICALS-HD demonstrates improvement in freedom from metastasis as well as freedom from non-p...
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