Given some of the theoretical relationship between glutamate and OCD, do you ever consider the use of NMDA (or AMPA) antagonists for the treatment of refractory OCD?

Answer from: at Community Practice

We recently published a systematic review and meta-analysis on glutamate-modulating agents in the treatment of OCD as augmenting agents to SSRIs or as monotherapy. Overall, we found that glutamatergic medications led to significant improvement (statistically and clinically) in OCD symptoms. We also ...

Comments

at Private Practice, General Psychiatry
Thank you so much for this helpful post.

at Private Practice
I have had success (about 40% of patients seeing b...

at Private Practice, General Psychiatry
Thank you for this. I've used NAC for quite a whil...

at Howard Center
Since NAC is over the counter and not regulated by...

at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS)
Great question! Others can also comment, but I&rsq...

at Private Practice
My wife made me try the powder form of NAC to see ...

at Thapar Renu K Office
Overall great discussion! Very helpful.

Agree

at Private Pratice
I have had great success using NAC to augment SSRI...

Answer from: at Community Practice

I will consider ketamine now as my results with amantadine and memantine have not been as significant.

Comments

at Kerzner Stephen D Office
I would be interested to hear others' experiences ...

at Private Practice
How about the use of dextromethorphan for TIA, str...

at Duke University
It would be nice to see some randomized and blinde...

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Given some of the theoretical relationship between glutamate and OCD, do you ever consider the use of NMDA (or AMPA) antagonists for the treatment of refractory OCD?

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