How do you approach initial serologic evaluation for patients referred with reactive lymphadenopathy, but no clear signs or symptoms of active rheumatologic disease?

Localized axillary adenopathy with uptake on PET. Excisional biopsy: benign lymph node with marked follicular hyperplasia consistent with reactive lymph node. No evidence of malignancy.

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How do you approach initial serologic evaluation for patients referred with reactive lymphadenopathy, but no clear signs or symptoms of active rheumatologic disease?

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