How do you assess whether an early-stage Hodgkin's patient is unfavorable?

I personally utilize the GHSG criteria for most patients. To review, a patient has "favorable" disease if they meet all of the following criteria:

1. 1-2 involved sites

2. No bulky disease

3. No extranodal disease (which is rare in early-stage HL)

4. Favorable ESR/B-symptoms profile (ESR < 30 with B...