Please select the option that best describes you:
Topics:
Hematologic Malignancies • Pediatric Hematology/Oncology • Medical Oncology • Lymphoma • Non-Hodgkin Lymphoma • Internal Medicine • Hematology
How do you choose your systemic treatment for primary mediastinal grey zone lymphomas?
Do you prefer a cHL chemotherapy backbone or PMBL chemotherapy backbone?
Answer from: Medical Oncologist at Academic Institution
Most of the literature (although not prospective) supports treating with an R-CHOP/EPOCH vs. traditional ABVD. As such, I tend to treat with R-DA-EPOCH. When I have had the unfortunate case of a relapsed/refractory patient, I have tended to treat with some of the newer HL salvage regimens.
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Answer from: Medical Oncologist at Community Practice
The specifics of the case would be relevant; patient age, presentation, and phenotype. I am more inclined to do R-EPOCH in general but may do ABVD instead if the case has more cHL like features.
Comments
at University of Minnesota Physicians
Presentation being huge anterior mediastinal mass ...
Presentation being huge anterior mediastinal mass ...
Medical Oncologist at Riverside Methodist Hospitals/OhioHealth
I would like to do A+AVD then per ECHELON-1 and co...
I would like to do A+AVD then per ECHELON-1 and co...
Medical Oncologist at UT MD Anderson Cancer Center
In addition to age, the stage and IPI would be hel...
In addition to age, the stage and IPI would be hel...
at University of Minnesota Physicians
13 years, Stage 2b, bulky disease, bone marrow neg...
13 years, Stage 2b, bulky disease, bone marrow neg...
Medical Oncologist at Riverside Methodist Hospitals/OhioHealth
I would also consider NGS for chromosome 9p24...
I would also consider NGS for chromosome 9p24...
at University of Minnesota Physicians
No cytopenias!
No cytopenias!
Answer from: Medical Oncologist at Academic Institution
Would agree with DA-EPOCH. Occasionally use consolidative radiotherapy for localized and/or bulky disease.