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Topics:
Hematologic Malignancies • Pediatric Hematology/Oncology • Medical Oncology • Hodgkin Lymphoma • Hematology
How would you counsel patients with personal or family histories of autoimmune disease on immune checkpoint inhibitor therapy for Hodgkin lymphoma?
Answer from: Medical Oncologist at Academic Institution
This is also a tough question. I think patients with autoimmune endocrinopathies (especially Hashimoto’s or Type 1 DM) on stable, longstanding replacement regimens, as well as pre-existing vitiligo, are reasonable candidates for frontline PD-1 based therapies, although they certainly bear very...
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Answer from: Medical Oncologist at Academic Institution
In patients with a personal history of active autoimmune disease, I typically recommend treatment with BV and AVD. In young patients, I recommend concomitant BV-AVD, and in older patients, I recommend sequential BV and AVD. In the relapsed/refractory setting, I would cautiously consider using a chec...
Answer from: at Community Practice
As per the protocol entry criteria for S1826, if a patient themselves has an autoimmune condition, I would not offer them a nivolumab/checkpoint-based regimen. The question of what to do in the setting of a family history: there is no data to answer this accurately- depending on the family hist...