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Topics:
Hematologic Malignancies • Pediatric Hematology/Oncology • Hodgkin Lymphoma • Internal Medicine • Hematology • Nuclear Medicine
How do you interpret a Deauville score of 3 on PET when performing mid-treatment assessments in patients with Hodgkin lymphoma?
Are there situations in which a Deauville 3 would cause you to escalate therapy?
Answer from: at Academic Institution
A Deauville score of 3 or less in an area of disease previously positive (Deauville score of 4 or 5) at interim assessment is considered to be a complete metabolic response (Lugano criteria, Cheson et al. JCO 2014). Some studies evaluating a de-escalation of therapy based on interim assessment may c...
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Answer from: at Academic Institution
It is also important in applying published protocols to see how the PET criteria held up when results were analyzed, if you wish to apply that treatment paradigm. For example in the GHSG HD15 trial which examined de-escalation of BEACOPP therapy from 6 or 8 cycles to 4 cycles, as written only DS 1 &...