How do you manage early stage I uterine serous carcinoma?

VC brachy, pelvic RT, +/- chemo?

Does your management change if it is confined to the endometrium without myometrium invasion or if it is only a endometrial polyp?

Answer from: Radiation Oncologist at Academic Institution

The management of these patients remains controversial. The data are conflicting and treatment choices tend to be based more on impressions than solid data. Most clinicians advocate chemotherapy although randomized trials have not clearly shown benefit for this subset. For stage IA, we typically tre...

Answer from: Radiation Oncologist at Community Practice

At present for surgically staged serous ca of endometrium, my philosophy is to treat like Grade 3 endometroid when deciding about radiation. As far as chemo, most gyne oncs would give adjuvant chemo irrespective of stage, although the recent GOG 249 presentation did not see a benefit...

Comments

Radiation Oncologist at MedStar Georgetown University Hospital
In patients that receive chemotherapy, would you s...

Radiation Oncologist at Varian Medical Systems/Allegheny health network
Our sequence is chemo first if they need EBRT.

Radiation Oncologist at Southcoast Centers for Cancer Care
@Patricia J. Eifel and @Sushil Beriwal, would pres...

Radiation Oncologist at Varian Medical Systems/Allegheny health network
Not unless it is extensive LVSI.

Answer from: Radiation Oncologist at Community Practice

Based on GOG 249, is it very reasonable to treat stage I or II uterine serous carcinomas, with negative peritoneal cytology, with pelvic radiation alone? Thank you

Comments

Radiation Oncologist at Vanderbilt-Ingram Cancer Center
It is technically reasonable. However, I would exe...

Radiation Oncologist at Mon Health
I agree, it is very reasonable to use Chemo + EBRT...

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How do you manage early stage I uterine serous carcinoma?

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