How do you manage early stage uterine carcinosarcoma?

Do you give cuff and chemo or pelvic CRT or chemo alone?

Answer from: Radiation Oncologist at Community Practice

Unfortunately, no good prospective study has shown an impact on survival with any adjuvant treatment. Based on relapse patterns at our institution for surgically staged IA disease, it is chemotherapy (ifosfamide plus taxol) plus cuff brachy. For all other stages, it is usually chemo as above followe...

Answer from: Radiation Oncologist at Academic Institution

Uterine carcinosarcomas are rare and considered high-risk variants of endometrial cancer which has a high chance of distant metastasis.There is no randomized trial of adjuvant treatment in stage I and II of carcinosarcoma alone except GOG #150 (stage I-IV). GOG #20 with stage I and II uterine sarcom...

Answer from: Radiation Oncologist at Academic Institution

Depends on what you mean by early stage.If you mean IA, NCDB suggests that for unfavorable histology (and for carcinosarcoma histology), chemotherapy and BT may help significantly, while EBRT may not. Seen regardless of whether is an endometrial polyp or < 50% MMI. Standard caveats of NCDB analys...

Comments

Radiation Oncologist at The Ohio State University Department of Radiation Oncology
I am assuming practice patterns haven’t chan...

Radiation Oncologist at Varian Medical Systems/Allegheny health network
Yes, except chemo for MMMT now is taxol and carbo ...

Radiation Oncologist at UAB Department of Radiation Oncology
No major changes except chemotherapy as above.

Radiation Oncologist at Allegheny Health Network
There is some data that depending on the sarcomato...

Radiation Oncologist at Vanderbilt-Ingram Cancer Center
Unfortunately, not a lot of headway has been made ...

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How do you manage early stage uterine carcinosarcoma?

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