How do you manage long-term xerosis and xerophthalmia in patients who have completed a course of isotretinoin?

Xeropthalmia can be a real problem. In a study in rabbits, we showed that isotretinoin in doses up to 1mg/kg has effects on meibobian glands similar to those on that occur in sebaceous glands. Meibum is responsible for preventing the tear film from evaporating. The third patient I ever treated devel...