How do you perform fertility counseling for a patient with a duplication of one of the alpha genes and their partner who has a beta chain point mutation?

That is, extra copy of one of the alpha genes resulting in an atypical alpha thalassemia for the patient, and beta thalassemia heterozygous carrier for the partner.

Answer from: at Academic Institution

There is a 25% chance that a fetus would inherit the alpha-globin genotype ααα:αα and a 25% chance of inheriting the beta-globin genotype βT:β. One family study suggested that the compound heterozygous genotype ααα:αα/βT:&bet...

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Medical Oncologist at BronxCare Mount Sinai Comprehensive Cancer Care
Thank you for your kind reply. I am copying the ge...

at Boston University School of Medicine
No. This is a beta0 mutation so perhaps, the chanc...

Medical Oncologist at BronxCare Mount Sinai Comprehensive Cancer Care
Thank you

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How do you perform fertility counseling for a patient with a duplication of one of the alpha genes and their partner who has a beta chain point mutation?

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