How do you sequence chemoradiation and chemotherapy for patients with locally advanced rectal cancer undergoing TNT based upon data from CAO/ARO/AIO-12?

In practice, does starting with chemoradiation followed by chemotherapy result in a significant delay in initiating chemotherapy or a patient's ability to tolerate 3-4 months of chemotherapy?

Answer from: Medical Oncologist at Community Practice

At our center, we give Total Neoadjuvant Therapy (TNT) for rectal cancer, with chemotherapy delivered up-front, followed by radiation (short-course vs long course chemo-XRT).We do not use the CAO/ARO/AIO-12 study as a blueprint for our approach. CAO/ARO/AIO-12 was a phase II study of TNT evaluating ...

Comments

Medical Oncologist at St Lukes Cancer Care Assocs
That's my approach too. What do you do post surger...

Medical Oncologist at Dartmouth Cancer Center, Dartmouth-Hitchcock Medical Center
Since adjuvant therapy is completed pre-operativel...

Medical Oncologist at Mayo Clinic
I agree with the above answers. For T4 and/or N2 (...

Medical Oncologist at Dartmouth Cancer Center, Dartmouth-Hitchcock Medical Center
I definitely agree that ctDNA is an important and ...

Please select the option that best describes you:

How do you sequence chemoradiation and chemotherapy for patients with locally advanced rectal cancer undergoing TNT based upon data from CAO/ARO/AIO-12?

Related Questions