How do you treat patients with symptoms of acute ischemic stroke who have an allergic reaction to alteplase?

How would you treat patients with symptoms of AIS who have an allergic reaction to TPA with no evidence of large vessel occlusion on imaging? What next steps would you do for stroke treatment?

Answer from: at Academic Institution

For patients with an allergic reaction (i.e. perioral or lingual edema, difficulty breathing, or other serious reactions), our protocol is to stop tPA (and not resume), discuss with the ED attending whether there is a need for epinephrine 0.3 mg (1:1000 dilution) or intubation, monitor respiratory s...

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at St Vincent Mercy
Thank you! Can the speed with which the bolus...

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How do you treat patients with symptoms of acute ischemic stroke who have an allergic reaction to alteplase?

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