How does sarcomatous overgrowth in a uterine carcinosarcoma change your management of adjuvant therapies?  

I tend to treat carcinosarcomas as high-risk endometrial cancers, with carboplatin/paclitaxel adjuvant chemotherapy, +/- vaginal cuff brachytherapy for early-stage disease. Adjuvant radiation for early-stage disease is also a consideration, as carcinosarcomas may have some improvement in local contr...