How will you adjust your approach to steroid taper in patients with PMR also on sarilumab?   

I would try to replicate the prednisone taper followed in the SAPHYR study that weaned patients off over 14 weeks, understanding that there may be patients that won’t be able to taper the prednisone so aggressively or may benefit, in the opinion of the treating physician, from longer tapers (e...

Historically, the general/recommended approach to steroid taper in PMR has been the following: starting at 12.5-25 mg (I usually start between 15-20 mg), decrease by 2.5 every 2-4 weeks to a dose of 10 mg, and then decreasing by 1 mg every 4 weeks until discontinuation. This taper regimen for steroi...