How would you approach isolated inguinal lymph node squamous cell carcinoma of occult primary?

If workup is negative for a primary lesion, would you consider prophylaxis of potential primary sites (anus/vulva?), and would you treat bilateral inguinal/pelvic nodes or use directed RT to the isolated site of gross disease?

Answer from: Radiation Oncologist at Academic Institution

Most of these are probably anal cancers, just based on the incidence and anatomy. One could certainly argue this either way (local only vs comprehensive). It is tempting to treat local only fields knowing that the salvage rate is probably high, but what has kept me from doing that is that compr...

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Radiation Oncologist at Berks Radiation Oncology Associates
Dr. @Christopher H. Crane, Would you consider ing...

Radiation Oncologist at Memorial Sloan-Kettering Cancer Center
If I was going to do a combined approach, I would ...

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How would you approach isolated inguinal lymph node squamous cell carcinoma of occult primary?

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