How would you approach multiply recurrent prostate cancer in a patient who has had both LDR and salvage HDR?

What would you consider if the recurrence occurs multiple times in the prostate? Salvage surgery if a candidate? HIFU or cryo? ADT?

Answer from: Radiation Oncologist at Academic Institution

Very carefully! The risk of GU and GI toxicity from any salvage therapy after both LDR and salvage HDR is very high. If there is a focal lesion identified on MR/PSMA that is distant from the bladder, urethra, and rectum, then maybe you can try a focal treatment. I'd be very careful because the risk ...

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Radiation Oncologist at Stanford University
Agreed. It appears there is a lesion at the base/b...

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How would you approach multiply recurrent prostate cancer in a patient who has had both LDR and salvage HDR?

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