How would you approach potential SBRT to liver metastases in a patient on a VEGF inhibitor?

Would you alter your SBRT dose? How long would you hold the VEGF inhibitor before and after? Does the primary matter (e.g. NSCLC vs. colorectal)?

Answer from: Radiation Oncologist at Academic Institution

For patients who are on VEGF inhibitors, I would be very careful with dosing of radiation to nearby bowel and I discuss holding VEGF inhibitors for a time before, during and after radiation. There have been multiple reports of in field toxicity, particularly with respect to bowel (liver SBRT frequen...

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Radiation Oncologist at UCLA | VA Greater Los Angeles Healthcare System
This is a great scenario in which to consider a tr...

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How would you approach potential SBRT to liver metastases in a patient on a VEGF inhibitor?

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