How would you manage a medically inoperable patient with an invasive squamous cell carcinoma of the oropharynx and extensive adjacent leukoplakia harboring pathologically-proven in situ disease?

What is your radiotherapy approach? How large is your treatment field, and for the leukoplakia/in situ disease, what is your dose?

Answer from: Radiation Oncologist at Academic Institution

Definitive chemo RT using hyperfractionation or SIB with weekly cisplatin. I would treat the CIS and reduce off of it at 64 Gy.

Comments

Radiation Oncologist at Generations Radiotherapy and Oncology PC
Very helpful. Thank you!

Radiation Oncologist at Ohio State University James Cancer Center
@William M. Mendenhall, can you comment in general...

Radiation Oncologist at University of Florida
Hyperfractionation is likely the best schedule for...

Radiation Oncologist at Ohio State University James Cancer Center
@William M. Mendenhall, many thanks and respectful...

Radiation Oncologist at University of Florida
We started using hyperfractionation in 1978 having...

Radiation Oncologist at Jacob E Locke MD PA
SIB 66/60/54 to keep the lowest dose level at 1.8/...