How would you manage a patient with family history of protein S deficiency, now with provoked VTE and low protein S?

Low protein S would need to be checked at the appropriate time.

• It should not be checked during acute thrombosis
• It should not be checked while the patient is on DOAC
• If the provoking factor was estrogen containing contraceptives, testing should not be performed until the patient has been off of est...

I agree with Dr. @Dr. First Last, and I would add that the "family history" can also be derived from situations where family members had thrombosis and were tested at the wrong time. For example: the mother of the patient was tested during the acute thrombotic setting and/or during coumadin therapy ...