How would you manage new symptomatic brain metastases (10-15) in a young woman with HER2+ metastatic breast cancer?  

A lot of nuance to answering this on a per-patient basis.First question, how symptomatic? (As in, are there bulky mets that we should be considering surgical management upfront plus this also guides my discussion about whole brain vs systemic)If not acutely symptomatic and requiring a crani/resectio...

In a young woman with HER2+ metastatic breast cancer and new symptomatic brain metastases (10-15 lesions not candidate for SRS), with controlled extracranial disease on trastuzumab and pertuzumab, the treatment strategy should prioritize CNS control quickly. If she is truly symptomatic and symptoms ...