How would you manage progressive diffuse (both cords and arytenoid) high grade dysplasia of the larynx, with no in-situ or invasive disease on biopsies?

Leukoplakia is present throughout but no exophytic masses seen.

Is radiation an option (dose/fractionation)? Surgery? PDT?

Answer from: Radiation Oncologist at Academic Institution

High grade dysplasia is CIS and behaves like T1 invasive SCC. 63 Gy in 28 fractions larynx only.

Comments

Radiation Oncologist at Washington University School of Medicine
I agree with Dr. @William M. Mendenhall, if limite...