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Topics:
General Internal Medicine • Hematology • Pediatric Hematology • Benign Hematology • Hemostasis/Thrombosis
How would you manage someone with antithrombin deficiency who has recurrent VTE on a DOAC?
APLA syndrome, obesity, non compliance ruled out and prefers another oral anticoagulation. Is higher dose of rivaroxaban or apixaban an option?
Answer from: at Academic Institution
There are no large scale controlled studies demonstrating outcomes of use of oral direct-acting anticoagulants (DOACs) in patients with hereditary thrombophilia. One can find published case reports demonstrating success, but the 'failures' likely do not get published. The general approach would be t...
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Answer from: at Academic Institution
I would consider Coumadin or an alternative NOAC.
Repeat eval to make sure there is not a second gene defect. Also consider antithrombin III prophylaxis.
Comments
Medical Oncologist
Is the INR goal with warfarin for the treatment of...
Is the INR goal with warfarin for the treatment of...
at Mayo Clinic
Good question. The INR goal is still 2 to 3.
Good question. The INR goal is still 2 to 3.