How would you treat ESRD patients on HD with locoregional squamous cell carcinoma of the anus?  

Both FU and MMC may be used but one must modify the treatment around the dialysis since the FU infusion will be removed with dialysis. You could use 5 day bolus 5FU and give bolus after dialysis. It would be better to use capecitabine however and try to schedule between dialysis episodes (for exampl...