In a patient with cardiac comorbidities, who meets ASTRO APBI criteria other than a positive margin, would you offer APBI in an attempt to reduce cardiac dose?   

There are still substantial uncertainties about the impact of specific risk factors on the local recurrence rate following PBI. A tumor-free margin width of less than 2 mm was associated with a high risk of local failure in a number of studies (Chen et al., PMID 16421922; Vicini et al., PMID 1730693...