In a patient with metastatic prostate cancer on abiraterone planning to start Radium-223, what is the minimum interval between the last dose of abiraterone and the first dose of Radium?  

In-vivo studies have shown abiraterone is rapidly absorbed after oral intake and bioavailability is <10% in fasting state. Abiraterone has a half-life of 12-24 hours and if the dose is not repeated, most of the administered drug should be eliminated within a few days. Based on this, I do not see ...