In a patients with bilateral Wilms' tumor with favorable features (>90% response to VAD, no anaplasia), what histopathologic criteria should be used to define a positive margin requiring focal RT to a partial nephrectomy bed?   

Does the initial partial nephrectomy excision need to have a negative margin? 

Is a re-excision of the suspect portions of the tumor bed based on frozen section allowable in order to obtain negative margins on final pathology and avoid RT?  

Would you consider the volume of the remaining kidney that would require radiation as a factor in deciding whether to offer focal RT?