In deciding between 3 versus 6 months of adjuvant therapy for colon cancer, how would you factor in the presence of isolated tumor deposits (staged as N1c), but negative lymph nodes?  

My approach to N1 and N1c is exactly the same. For T4 N1/N1c disease, I offer 6 months of adjuvant FOLFOX or CAPOX. For T1-3 N1/N1c disease, I favor 3 months of adjuvant chemotherapy with CAPOX as the preferred regimen.