In light of the recently published OPRA trial, could one consider organ preservation as a standard treatment option for appropriately selected patients treated with total neoadjuvant therapy for locally advanced rectal cancer?   

I think that it is NOT appropriate to consider watch and wait as a standard therapy. The OPRA trial did not test that concept- they just showed that they get pretty good results at 3 years using this technique when compared to historical data. They have not done any type of randomized comparison dem...

Multidisciplinary teams could establish watch and wait as an option. The key component is the surgical expertise to recognize local regrowth. If that is in place, there does not appear to be an oncologic downside to offering that option. The salvage rates are extremely high among patients whose tumo...