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Breast Cancer • Radiation Oncology
In what clinical scenario, if any, would you consider APBI appropriate treatment for a patient with triple-negative breast cancer?
Would you consider APBI for an ER/PR/HER2 negative pT1-2 N0 with pathologic complete response after neoadjuvant chemotherapy?
Would the presence of breast augmentation with implants move the risk-benefit ratio in favor of APBI?
NSABP 39 included 19% on each arm where ER/PR was negative
Answer from: Radiation Oncologist at Community Practice
Currently, none of the prospective studies did APBI after neoadjuvant chemotherapy so that subset, we don't offer APBI (need studies in this space).As far as denovo early-stage TNBC, we have not been doing APBI as were only part of one (B39) of all prospective randomized studies with PBI and also sh...
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Answer from: Radiation Oncologist at Academic Institution
Agree regarding PBI after NAC with @Sushil Beriwal.We only offer whole breast radiation after neoadjuvant therapy for TNBC. Although, I suspect it’s one of these ‘it might be fine’ things, but we still won’t do it.But we have chosen to offer PBI for small ER negative disease ...
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Radiation Oncologist at Cleveland Clinic
I offer for ER- DCIS but have not for ER- invasive...
I offer for ER- DCIS but have not for ER- invasive...