Is angioedema secondary to IV tPA considered an absolute contraindication for tPA in future?
Answer from: at Academic Institution
In short, no. In general, the only absolute contraindications to alteplase and other forms of tPA are active bleeding or situations that could result in active uncontrollable bleeding; all other considerations are relative. Hemi-orolingual angioedema is thought to arise associated with activation of...
From Bianca Pirlog MD and James Grotta MD; Houston Mobile Stroke Unit, Memorial Hermann Hospital, Houston, Texas.As Dr. @Michael D. Hill already mentioned, the angioedema post tPA seems to be associated with activation of the kallikrein system and it seems that patients under ACE inhibitors are at i...