Is APBI appropriate in post menopausal women with small, triple negative breast cancers excised with negative margins?  

We do have data to suggest that these patients do poorly with mastectomy alone vs other t1/t2 patients: Wang et al., PMID 21852010 Abdulkarim et al., PMID 21670451 Extrapolating from that, biologically, these seem to be more aggressive both locoregionally (despite mastectomy/removal o...

I haven't done PBI for TNBC, mostly based on institutional series. Local recurrence was 20% at 5 years on the Wisconsin series (Cannon et al., PMID 23709055) and 33% at 5 years on the MGH series (Pashtan et al., PMID 22652104). I would consent patients with these numbers as possible outcomes b...

I'm not sure histological type or receptor status predicts where the tumor is likely to fail. My presumption is that triple negative tumors would have a higher recurrence rate - not that they would recur more likely outside the cavity. The past "suitability" criteria did not list a reference showing...