Is chronic major salivary gland enlargement in a patient with Sjogren's an indication for immune-modulating therapy such as hydroxychloroquine or methotrexate?  

Although there have been 2 patients reported to have an improvement in parotid size with hydroxychloroquine and methotrexate are generally ineffective for the treatment of chronic bilateral major salivary gland enlargement in Sjogren's. For acute bilateral swelling, a tapering dose of prednison...