Is it appropriate to treat a Stage IE DLBCL of the cervix with close followup if a CR is achieved after 4 cycles of R-CHOP followed by a hysterectomy omitting RT?   

The role of involved site radiotherapy after effective chemotherapy is to treat sites of previously known disease, not to address unknown regions of micrometastatic disease. If the gross disease was confined to the cervix and/or uterus, a hysterectomy is an acceptable substitute for consolidative ra...