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Is it possible for certain individuals with osteoporosis to be a denosumab "non-responder"?
I’ve seen several such patients who have no secondary causes for bone loss, on adequate calcium/vitamin D, and compliant with denosumab who do not show improvement in BMD despite several doses. Although neutralizing antibodies to denosumab were not detected in the clinical trials, I am curious to know if this is something that people suspect or if there are other causes for treatment failure.
Answer from: at Community Practice
As far as I know, there are non-responders to every drug. There are 2 considerations that you should particularly consider, and which you could address. First, does the patient have an unrecognized secondary cause for low bone mass or fracture? It is really important to reevaluate a patient who is n...
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