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Gastrointestinal Cancers • Medical Oncology
Is it safe to continue/re-challenge oxaliplatin in patients with oxaliplatin-induced hepatic sinusoidal injury and splenomegaly?
This is specifically in regards to metastatic colon cancer with good disease control of disease on FOLFOX and preserved hepatic function.
Answer from: Medical Oncologist at Community Practice
Typically, if there is documented hepatic injury, I will not revisit oxaliplatin as continued therapy will result in continued injury that may limit future therapeutic options. Given that many GI oncology patients will receive multiple agents that are metabolized through the liver and/or have ...
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