Is it safe to offer breast/chest wall radiotherapy while a patient is receiving Perjeta?  

The question of concurrent pertuzumab and radiation in the palliative setting will likely come up more often now with the recent striking improvement in overall survival of 15.7 months in stage IV HER2+ patients treated with docetaxel pertuzumab and trastuzumab as compared with docetaxel and hercept...

I treated a patient for spine met while on Herceptin and perjeta and the side effects were much more extreme than usual. The patient was admitted with radiation esophagus, could not swallow and EGD showed a very deep circumferential ulcer consistent with radiation.  In this situation I am conv...

The data is not there because the Perjeta with Herceptin plus chemo trial (showing high pCR rate) which led to its aproval was in the neoadjuvant setting for 6 cycles. None of the patients in that study had RT with Perjeta. In the adjuvant setting, these patients got herceptin alone. The NCCN guidel...