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Is there an effective treatment for severe radiation fibrosis of the skin after radiotherapy to the breast or other areas?
I have heard of long-term pentoxifylline and Vitamin E daily combination that can prevent and even reverse radiation fibrosis (Delanian et al., PMID 12829674). How effective is this and is this used commonly in practice? Any topical agents that are helpful?
Answer from: Radiation Oncologist at Academic Institution
I have used this regimen occasionally with moderate success. Worth a try. Topical Vitamin E as well can help.
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Answer from: Radiation Oncologist at Community Practice
I have had occasional successes with breast fibrosis. In the absence of other regimens, it's worth a 6-month trial.
Answer from: at Community Practice
I have only had a handful of patients with chronic radiation fibrosis in the last 6 years, but 3 of them benefited from Ultrasound therapy from a PT office that offers it.
The data behind this treatment comes from reports of Ultrasound therapy utilized to treat Lipodermatosclerosis.
These patients...
Answer from: Radiation Oncologist at Academic Institution
I have not been terribly impressed with the effectiveness of this regimen and have yet to find anything I am confident in recommending to patients who have significant radiation-induced fibrosis. For patients with associated pain, I've had modest success using gabapentin or similar agents.
Answer from: at Academic Institution
Would you ever recommend pentoxifylline + Vitamin E to prevent fibrosis before it has occurred?
Comments
Radiation Oncologist at Wellspan Sechler Family Cancer Center
I do in very large breasted patients or otherwise ...
I do in very large breasted patients or otherwise ...