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Topics:
Breast Cancer • Radiation Oncology
Is there any data to support SLNB instead of ALND in patients with clinically N2-3 breast cancer after neoadjuvant chemotherapy?
Alliance Z-1071 cohort had 5% with cN2 and <1% fixed or matted and the current Alliance trial 011202 only allows cN1. ALND has never been shown to improve survival.
Answer from: Radiation Oncologist at Community Practice
The sentina trial and acsog trial had Predominant N1 disease and negative predictive value Of SNLN is not known for N2 or N3 disease
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