Should platelet transfusions be considered for anti-platelet agent reversal in patients with major bleeding?  

Patients on plavix and/or aspirin are at risk for bleeding whether in relation to surgery or bleeding from the gi tract. Much like the management of patients on anticoagulation temporary reversal of antiplatelet drugs is only achieved by normalizing platelet function. This is the same principle used...

Baharoglu et al., PMID 27178479.The only high-quality evidence demonstrates harm with platelet transfusion to reverse anti-platelet agents. So my answer is don't do this, particularly if the PFA 100 is near normal or normal, and there is no systemic indication of hemostatic defect. In other words, i...