What adjuvant therapy would you offer a patient with Stage II uterine serous carcinoma without lymph node sampling?  

Since the major concern for UPSC is distant mets, these patients typically first receive 6 cycles of carboplatin/taxol after surgery at our institution. If the patient tolerates it without significant toxicity and re-staging scans are clear, we would then offer whole pelvis RT (45 Gy in 25 fractions...

I would get staging scans done as part of the workup, as the risk of extrauterine disease is high based on incompletely staged II disease.  One can consider surgical staging including nodal dissection and omental sampling (the likelihood of upstaging is as high as 30% or so) and then adjuvant ...

I agree with chemoradiotherapy for this patient. The majority of the patients with serous tumors in PORTEC-3 had p53 mutations and so would be expected to benefit. I suspect we will be treating far few EC patients with chemotherapy, as we will be able to treat based on genotype rather than rely so m...