What adjuvant therapy would you offer to a young patient with resected margin-negative stage III extrahepatic cholangiocarcinoma?  

I would strongly consider using the @Edgar Ben-Josef SWOG 0809 trial of chemotherapy and chemoRT adjuvantly - this is assuming you have a radiation oncologist who is also supportive. This is more positive data than the BILCAP study, which showed a *very* modest effect of adjuvant capecitabine P...