What are your preferred target doses for bulky T4 rectal adenocarcinomas with extensive GU and anal sphincter involvement as well as common illiac and inguinal adenopathy, as part of total neoadjuvant therapy when future APR is planned?

Often what you think may be CI LAD is actually mesocolic LAD and will be removed at the time of surgery. If there is no internal or external iliac LAD that is likely the case and regardless the surgeons can easily remove them in most cases opposed to internal iliac nodes, which are a challenge due t...