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What dose and target volume do you use for neoadjuvant chemoRT in a patient with a locally advanced uterine/endometrial cancer involving parametria, cervix, and the uterine fundus (no side wall involvement) requiring downstage to be eligible for surgery?
Her primary disease is too large for any brachytherapy; if substantial residual disease remains, how would you approach external beam boost?
Answer from: Radiation Oncologist at Academic Institution
Presuming that this is an endometrioid cancer - I would start with RT +/- chemo. There is potential for there to be sufficient shrinkage to facilitate brachytherapy boost. I do appreciate the link Dr. @Price published, and would consider doing SBRT with a neoadjuvant dose how we would as per Dr. @Be...
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Answer from: Radiation Oncologist at Community Practice
This is our series and approach; Vargo et al., PMID 25218303.A few points in this series did have interstitial brachytherapy with the goal of focusing more on areas where downsizing will make surgery feasible.
Comments
Radiation Oncologist at New York Cancer and Blood Specialists
Thank you. Do you still boost even if the mass is ...
Thank you. Do you still boost even if the mass is ...
Radiation Oncologist at Fox Chase Cancer Center
I would also keep this paper in mind, newly publis...
I would also keep this paper in mind, newly publis...
Radiation Oncologist at Allegheny Health Network
Up front chemotherapy (and IO) can also be enterta...
Up front chemotherapy (and IO) can also be enterta...