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What dose do you prescribe when treating the prostate in patients with low metastatic burden and what are your dose constraints?

The STAMPEDE trial recently published in Lancet used 55 Gy in 20 fractions but did not include dose constraints.
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Radiation Oncology · Cleveland Clinic
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I follow the STAMPEDE regimen - either 55 Gy in 20 daily fractions or 36 Gy in 6 weekly fractions. One of the imperatives of the STAMPEDE investigators was to not subject men with low volume metastatic prostate cancer to toxicity - and they found these doses of did not, while still significantly imp...

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Radiation Oncology · Duke University School of Medicine
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STAMPEDE also allowed 55 Gy in 20 fractions. I use the 60 Gy in 20 fraction regimen proven safe in CHHiP and PROFIT.

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Radiation Oncology · Virginia Commonwealth University Medical Center
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We've been debating this issue at our institution, too. STAMPEDE also used a 6 Gy x6 delivered one fraction per week regimen.

As these are patients likely to live a long time, even if not cured, then the goal in treating the prostate should be to achieve durable local control, while at the same time...

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Radiation Oncology · Karmanos Cancer Institute - McLaren Proton Therapy Center
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Converting to U.S.-style 5 fraction prostate SBRT, would anyone give 7.25 Gy per fraction x 5 fractions for 36.25 Gy, or use a different dose? Treating once weekly, twice weekly, or thrice weekly?

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