What dose do you recommend for salvage radiotherapy after biochemical recurrence in prostate cancer?

We normally give dose of 66.6 Gy which should be sufficient for microscopic disease. In patients where there is imaging suggesting recurrence or the pre-RT PSA is high then we consider going to 70 Gy for a high volume of disease while taking normal tissue dose into account.

There is data for dose esc...

The only RCT testing dose-escalation in the salvage setting is the SAKK 09/10 (64Gy vs 70Gy). 70Gy was associated with low rates of acute grade 2-3 GU and GI toxicity, and minor impact in QoL. Biochemical control data to be reported soon.