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Topics:
Radiation Oncology • Genitourinary Cancers
What fractionation regimen do you use for combination EBRT and HDR for high-risk prostate cancer?
Is a single-fraction HDR boost appropriate following conventionally fractionated EBRT to 45-50.4Gy?
Answer from: Radiation Oncologist at Community Practice
There is a range of appropriate HDR boost fractionation options.The 2018 NCCN Guidelines list the following options:45-50.4 Gy + 10.75 Gy x 237.5 Gy (2.5 Gy fractions) + 12-15 GyRTOG 0815 (allows brachy boost as an option): 45 Gy +10.5 Gy x 2RTOG 0924 (allows brachy boost as an option): 45Gy+ 15Gy x...
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Answer from: Radiation Oncologist at Academic Institution
The best evidence for fractionation schedule in combination with 15 Gy HDR boost is the 37.5 Gy in 15 fraction schedule. In my practice at UVA, I start with the prostate HDR boost (15 Gy in 1 fraction), which allows me to place prostate-rectal spacer at time of brachytherapy. Then, I use 45 Gy in 1....