What group of early pancreatic cancer patients, such as pT1a, can be excluded from adjuvant chemotherapy post resection?   

Short answer is none - all patients who have undergone surgery for pancreatic cancer benefit from adjuvant chemotherapy, as long as they can tolerate it.But to be a bit more detailed: Both the Neoptolemos, ESPAC-4 adjuvant trial of gem+cap, and the Conroy PRODIGE 24–ACCORD adjuvant trial of F...

I agree with my colleagues above and as Dr. @Kasi stated, this is a topic that sometimes comes up on tumor boards.Large databases such as NCDB are in no way a substitute for RCTs but may provide additional information. Two relatively recent NCDB studies looked at the benefit of adjuvant chemo f...